A physician-prescribed blend of two peptides that signal the pituitary gland to release growth hormone. Evaluated by a licensed Apex Meds provider and filled by a licensed U.S. pharmacy.
CJC-1295 is a modified copy of the first 29 amino acids of growth-hormone-releasing hormone (GHRH), the signal your brain already uses to call for growth hormone. Ipamorelin is a five-amino-acid peptide that mimics ghrelin at a second, separate receptor.
Neither one is growth hormone. Both ask your pituitary gland to release its own, which keeps your body's feedback loops in the picture.
What the research shows
A single dose of long-acting CJC-1295 raised average growth hormone two to ten times for six days or more.
Human studyThe same trials saw IGF-1 rise one and a half to three times for nine to eleven days.
Human studyIn healthy men, baseline growth hormone rose while the body's own pulsing pattern was preserved.
Human studyHuman studies measured hormone levels only. These outcomes have not been tested in trials.
Not yet studied
People who want to understand their growth hormone axis as they age.
People who train hard and want physician oversight rather than guesswork.
People who ask about growth hormone because of how they sleep and recover.
People who want lab monitoring of IGF-1 and glucose built into the plan.
These describe the people who ask about CJC-1295 / Ipamorelin, not results. A licensed provider decides whether it is appropriate for you.
CJC-1295 binds the GHRH receptor on the pituitary cells that make growth hormone. Ipamorelin binds the growth hormone secretagogue receptor. Because they work through different doors, the two are paired on the reasoning that the combined signal is stronger than either alone.
Released growth hormone then prompts the liver to make IGF-1, which carries out much of growth hormone's downstream work. Your provider tracks IGF-1 to see how you are responding.
Two receptors on the cells that make growth hormone
Your body's own release, prompted rather than supplied
Makes IGF-1, which your provider tracks
A small injection just under the skin, usually in the evening on an empty stomach. Your provider sets the dose and the weekly schedule and teaches you the technique. It arrives already reconstituted by the pharmacy, so there is no powder to mix and nothing to measure out.
Patients most often describe changes in sleep and recovery first, with body-composition changes later. These are patient reports, not trial outcomes, and results vary.
Growth hormone signalling can raise blood sugar, so your provider checks IGF-1 and glucose markers at baseline and again during treatment.
No. These peptides signal your pituitary gland to release your own growth hormone rather than supplying it. Human studies confirm they raise growth hormone and IGF-1, which is different from proving a specific clinical benefit.
No. Neither peptide is approved by the FDA for any condition. When prescribed it is a compounded medication, which has not been reviewed by the FDA for safety, effectiveness or quality.
That has not been demonstrated in human clinical trials of these peptides. Studies in people measured hormone levels. Your provider will talk through what is realistic for you.
As a small subcutaneous injection, usually in the evening. Your provider sets the dose and schedule and monitors your labs.
The most commonly reported are injection-site irritation, flushing, headache, water retention and increased appetite. Blood sugar can rise, which is why labs are monitored. Long-term safety has not been studied.
No. CJC-1295 and ipamorelin are both named on the World Anti-Doping Agency Prohibited List and are banned at all times, in and out of competition. Military members should also check their service's prohibited list.
Your provider reviews your full history, so tell them about every medication and condition, including any history of cancer. Reported side effects: redness or irritation at the injection site; flushing or headache; water retention or joint discomfort; increased appetite; a possible rise in blood glucose. Who should not use it: active cancer or a recent history of cancer; pregnancy or breastfeeding; uncontrolled diabetes; significant heart disease; athletes subject to drug testing.
BPC-157 and TB-500 together: the two most talked-about recovery peptides, prescribed as one protocol and overseen by a physician.
The Wolverine pairing with GHK-Cu added: a copper-carrying peptide your body makes naturally and that has been studied for skin.
A 15-amino-acid peptide modelled on a protective protein from the stomach, studied in animal models for tendon, muscle and ligament repair.
Answer a few questions. A licensed Apex Meds provider decides whether it is right for you.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Prescription products require an online evaluation with a licensed medical professional, who will determine whether a prescription is appropriate. Compounded medications are not FDA-approved and have not been evaluated by the FDA for safety, effectiveness or quality. Research cited on this site describes published studies and is not a claim about what any product will do for you. Individual results vary.
